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gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug, and what the pooled trial data show.

8 questions · sorted by votes

31 votes 5 answers52k views
Does a slower rate of loss reduce gallstone risk in practice?

For the avoidance of doubt, nothing here is urgent — I would be in a clinic rather than a text box. This is one of those things that everyone repeats and nobody…

gallbladder
gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug,…

8 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
asked by ines_delacruz 16k · 20 months ago
28 votes0 answers14k views
What incidence of cholelithiasis did the trial programmes report?

I am asking about the pattern rather than about my own management, which is elsewhere. I can parse the result. I am less sure what it licenses me to conclude. I have…

gallbladder
gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug,…

8 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questions
asked by Dr_Aoife_Brennan 20k · 19 months ago
27 votes 3 answers11k views
Why did my LDL-C rise 22% during the fastest phase of weight loss?

Twelve weeks in, losing roughly 1.1 kg a week, and my fasting LDL-C has gone from 2.7 to 3.3 mmol/L. Total cholesterol up from 4.6 to 5.2. Triglycerides down from 1.9…

lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

139 questions
bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

296 questions
gallbladder
gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug,…

8 questions
hydration
hydration

Fluid intake when thirst and intake cues are both blunted: how much of the early scale drop is fluid, how dehydration confounds a renal panel, and…

14 questions
asked by elke_brunner 17k · 14 months ago
27 votes3 answers7.8k views
Is gallbladder wall thickening on an incidental scan meaningful here?

Timing, since it always gets asked: this started nine days after a dose step. I want to understand what this actually establishes, as opposed to what it is being used…

gallbladder
gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug,…

8 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questions
asked by tobias_reint 20k · 6 months ago
26 votes 5 answers44k views
Is ursodeoxycholic acid prophylaxis supported by anything in this population?

I am asking about the pattern rather than about my own management, which is elsewhere. I am asking for verification rather than opinion, ideally with something I can…

gallbladder
gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug,…

8 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
asked by bac_or_bust 33k · 2.2 years ago
19 votes 5 answers25k views
Does gallbladder risk persist once weight has stabilised?

I have kept a symptom diary against dose dates, which turns out to have been the useful thing. The empirical answer seems settled. The explanation does not. If the…

gallbladder
gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug,…

8 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
plateau
plateau

A stall in progress: distinguishing adaptive thermogenesis from measurement error from adherence drift, how long to observe before changing…

36 questions
asked by forty_units 16k · 16 months ago
8 votes3 answers10k views
Does the reported gallbladder risk track the drug or the rate of loss?

I am asking about the pattern rather than about my own management, which is elsewhere. I understand the observation; what I do not understand is the mechanism behind…

gallbladder
gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug,…

8 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

10 questions
asked by label_claim 30k · 16 months ago
2 votes 4 answers19k views
How do I tell biliary colic from ordinary upper-abdominal discomfort?

For the avoidance of doubt, nothing here is urgent — I would be in a clinic rather than a text box. The figures are clear enough; the question is what they mean and…

gallbladder
gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug,…

8 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
asked by oona_kekkonen 13k · 2.3 years ago
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