ALT, AST, GGT and ALP: what they do and do not indicate about hepatic fat, why enzymes are a poor surrogate for histology, and where non-invasive fibrosis scores fit.
What I am working with: ALT · mazdutide. I would like to set this up properly once, rather than adjust it repeatedly. My budget is real but not tight, and my…
Stated plainly: lipase · a GLP-1 receptor agonist. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would…
What I have: TSH · dulaglutide. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how confident the…
The case in front of me: HbA1c · liraglutide. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically,…
Conditions: potassium · semaglutide. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles that come…
Details up front: ApoB · retatrutide. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I would…
Conditions: GGT · oral semaglutide. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is an…
Stated plainly: ALT · AST · semaglutide. Both of these get recommended confidently by different people, which suggests neither is obviously right. My constraints are…
The specifics, since they change the answer: AST · ALT · a GLP-1 receptor agonist. The comparison I want does not seem to exist anywhere in a form I can evaluate. I…
The specifics, since they change the answer: AST · ten weeks · a GLP-1 receptor agonist. Something has gone wrong and I would like to know how badly before I decide…
The case in front of me: GGT · albumin-to-creatinine ratio · orforglipron. I would like the axes of comparison first and the recommendation second. I have tried the…
Stated plainly: LDL-C · cagrilintide. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My background is…
The specifics, since they change the answer: albumin-to-creatinine ratio · dulaglutide. I suspect the usual explanation for this is wrong, or at least incomplete. I…
Details up front: GGT · oral semaglutide. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow the plan I write…
Details up front: GGT · tirzepatide. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow the plan I write down,…
The specifics, since they change the answer: lipase · cagrilintide. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody…
What I am working with: GGT · four weeks · dulaglutide. I think I have a problem. I am not yet sure whether it is a real problem or a measurement artefact. I want to…
Details up front: ferritin · liraglutide. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is an…
Stated plainly: eGFR · orforglipron. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how confident…
Concretely: eGFR · dulaglutide. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how confident the…
Stated plainly: triglycerides · ecnoglutide. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried to…
Details up front: ALT · cagrilintide. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My background is…
For reference: GGT · albumin-to-creatinine ratio · dulaglutide. I would like the axes of comparison first and the recommendation second. I have tried the first option…
Stated plainly: ALT · mazdutide. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My background is…
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