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weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us about partial dosing.

10 questions · sorted by votes

54 votes 3 answers41k views
What does the regain curve actually look like after stopping, and how fast does it happen?

I am going to have to stop, not by choice: my supply arrangement is ending and the alternative is not affordable for me long term. I have gone from 108 kg to 79 kg…

discontinuation
discontinuation

Stopping treatment: tapering versus abrupt cessation, what the trial withdrawal arms measured, clinically driven stops, and the practical planning…

21 questions
weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

10 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

54 questions
asked by thabo_maseko 28k · 21 months ago
49 votes 3 answers15k views
Is there any pharmacological reason to taper rather than just stop, or is that a placebo ritual?

I am planning to come off semaglutide 2.4 mg and everyone has an opinion about tapering. The suggestions I have been given range from "step down 2.4 to 1.7 to 1.0 to…

discontinuation
discontinuation

Stopping treatment: tapering versus abrupt cessation, what the trial withdrawal arms measured, clinically driven stops, and the practical planning…

21 questions
maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

54 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

10 questions
asked by Dr_Signe_Baldursdottir 29k · 11 months ago
30 votes 5 answers49k views
How much of the first four weeks of loss is fluid?

I am training twice a week and would rather optimise that than add a third session. I can do the algebra. I am not confident about the conversion factors. If there is…

plateau
plateau

A stall in progress: distinguishing adaptive thermogenesis from measurement error from adherence drift, how long to observe before changing…

36 questions
hydration
hydration

Fluid intake when thirst and intake cues are both blunted: how much of the early scale drop is fluid, how dehydration confounds a renal panel, and…

14 questions
weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

10 questions
asked by m_haraldsen 21k · 2.3 years ago
26 votes5 answers14k views
Is an AHI improvement durable if weight is regained?

My laboratory results are from the same laboratory each time, drawn fasting, which I gather matters. This is one of those things that everyone repeats and nobody…

sleep-apnea
sleep-apnea

Obstructive sleep apnoea and the apnoea-hypopnoea index response to weight loss, including the SURMOUNT-OSA dataset and the question of whether…

6 questions
weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

10 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
asked by tare_and_weigh 12k · 15 months ago
22 votes 5 answers7.6k views
What does the withdrawal-extension data say about regain trajectory?

Scale weight, waist circumference and a repetition maximum, all logged weekly. I would like help reading this properly rather than being told what conclusion to…

weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

10 questions
discontinuation
discontinuation

Stopping treatment: tapering versus abrupt cessation, what the trial withdrawal arms measured, clinically driven stops, and the practical planning…

21 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
asked by felix_araya 6.8k · 6 months ago
12 votes 5 answers31k views
Is tapering better supported than stopping abruptly?

I have three DEXA scans on the same scanner at twelve-week intervals, fasted, same time of day. I would like to know whether this claim survives contact with…

discontinuation
discontinuation

Stopping treatment: tapering versus abrupt cessation, what the trial withdrawal arms measured, clinically driven stops, and the practical planning…

21 questions
maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

54 questions
weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

10 questions
asked by mira_sundqvist 7.1k · 2.1 years ago
9 votes 3 answers8.6k views
Is a four-month stall adaptive thermogenesis or measurement error?

Intake is tracked, imperfectly, and I am aware of the direction of the error. I think I have a problem. I am not yet sure whether it is a real problem or a…

plateau
plateau

A stall in progress: distinguishing adaptive thermogenesis from measurement error from adherence drift, how long to observe before changing…

36 questions
weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

10 questions
dexa
dexa

Dual-energy X-ray absorptiometry: what it measures, its precision limits, why hydration state and scan positioning move the numbers, and how to…

39 questions
asked by lucia_marchetti 19k · 8 months ago
8 votes3 answers10k views
Does the reported gallbladder risk track the drug or the rate of loss?

I am asking about the pattern rather than about my own management, which is elsewhere. I understand the observation; what I do not understand is the mechanism behind…

gallbladder
gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug,…

8 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

10 questions
asked by label_claim 30k · 16 months ago
4 votes5 answers19k views
What is the lowest maintenance dose with published maintenance data behind it?

I have been on a stable schedule for eleven weeks, so this is not a first-week question. I am asking for verification rather than opinion, ideally with something I…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

54 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

10 questions
asked by claudia_ferrante 22k · 2.3 years ago
2 votes5 answers13k views
Does positional apnoea respond differently to weight loss?

The clinician who ordered the panel was not concerned; I would still like to understand it. I want to know whether this is a real physical effect or an artefact of…

sleep-apnea
sleep-apnea

Obstructive sleep apnoea and the apnoea-hypopnoea index response to weight loss, including the SURMOUNT-OSA dataset and the question of whether…

6 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

10 questions
asked by noor_alhassan 11k · 14 months ago
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