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nausea

Page 3 of 3 · 55 questions tagged nausea.

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55 questions · sorted by votes · page 3 of 3

8 votes 5 answers4.4k views
Does nausea at week ten of retatrutide usually resolve without a dose change?

The particulars: nausea · ten · retatrutide. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questionstitration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsretatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questionsasked by haze_check 9.3k · 10 months ago
7 votes0 answers875 views
Does holding at a lower dose for longer reduce total side-effect burden?

My records go back to the first dose with dates, so I can reconstruct the timeline exactly. I keep seeing this stated as a fact with no explanation attached, and…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsnausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questionsgi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questionsasked by gel_pack_warm 13k · 22 days ago
4 votes 4 answers5.2k views
Does holding at 0.25 mg for twelve weeks before escalating reduce nausea?

Conditions: 0.25 mg · twelve weeks · nausea. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsnausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questionsdose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questionsasked by halvard_ness 69k · 14 months ago
4 votes0 answers4.6k views
What does STEP 8 tell me about nausea at the 2 mg dose?

For reference: STEP 8 · nausea · 2 mg. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questionsnausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questionstitration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsasked by greta_holzmann 23k · 19 months ago
3 votes 5 answers4.3k views
Does nausea at week four of semaglutide usually resolve without a dose change?

The case in front of me: nausea · four · semaglutide. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questionstitration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionssemaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questionsasked by fib4_reader 24k · 3 months ago
2 votes 5 answers6.3k views
Is nausea dose-dependent or dose-rate dependent?

No other medication changes, no dietary changes, nothing else obviously confounding. I want to know whether this is a real physical effect or an artefact of how it is…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questionstitration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsgi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questionsasked by thabo_maseko 28k · 14 months ago
2 votes0 answers896 views
Does holding at 12.5 mg for eight weeks before escalating reduce nausea?

What I am working with: 12.5 mg · eight weeks · nausea. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsnausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questionsdose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questionsasked by sample_id 17k · 12 months ago