PeptideStack
5.2kquestions
20kanswers
220users

nausea

Page 2 of 3 · 55 questions tagged nausea.

55 questions · sorted by votes · page 2 of 3

21 votes0 answers6.7k views
What does STEP 8 tell me about nausea at the 1 mg dose?

The specifics, since they change the answer: STEP 8 · nausea · 1 mg. I want to understand what this actually establishes, as opposed to what it is being used to…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by lucia_marchetti 19k · 4 months ago
18 votes 3 answers35k views
Is nausea on mazdutide dose-dependent or dose-rate dependent?

Details up front: nausea · mazdutide. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would rather hear…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
mazdutide
mazdutide

A GLP-1 and glucagon receptor dual agonist developed primarily in China, with a distinct dose range and a fast-moving publication record.…

237 questions
asked by teodora_ilic 17k · 23 months ago
18 votes 3 answers22k views
What is the reported incidence of nausea on semaglutide in SUSTAIN-6?

Conditions: nausea · semaglutide · SUSTAIN-6. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by stopper_core 28k · 22 months ago
18 votes1 answer10k views
What did the placebo arm of SURMOUNT-4 report for nausea?

Numbers first: SURMOUNT-4 · nausea. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
asked by RP_C18 105k · 8 months ago
18 votes5 answers10k views
What is the reported incidence of nausea on oral semaglutide in SOUL?

The particulars: nausea · oral semaglutide · SOUL. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
oral-glp1
oral-glp1

Oral routes for GLP-1 receptor agonism: peptide formulations rescued by absorption enhancers such as SNAC, and true small molecules that need no…

219 questions
asked by ivo_paunovic 16k · 15 months ago
18 votes 5 answers5.3k views
Does holding at 12.5 mg for twelve weeks before escalating reduce nausea?

The case in front of me: 12.5 mg · twelve weeks · nausea. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by swab_and_wait 13k · 8 months ago
16 votes 5 answers8.4k views
What did the placebo arm of SELECT report for nausea?

Concretely: SELECT · nausea. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree, which is…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
asked by Dr_Marek_Zielinski 27k · 10 months ago
15 votes5 answers17k views
Does nausea at week eight of ecnoglutide usually resolve without a dose change?

Details up front: nausea · eight · ecnoglutide. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the theory.…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
ecnoglutide
ecnoglutide

A long-acting GLP-1 receptor agonist with a cAMP-biased signalling profile. A niche tag, mostly used for mechanism questions about biased agonism…

223 questions
asked by coldbox9 41k · 23 months ago
15 votes 5 answers12k views
Is nausea on liraglutide dose-dependent or dose-rate dependent?

The specifics, since they change the answer: nausea · liraglutide. I want to know whether this is a real physical effect or an artefact of how it is measured. What…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
liraglutide
liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

235 questions
asked by imani_dube 8.9k · 2.3 years ago
15 votes 5 answers12k views
Does nausea at week four of survodutide usually resolve without a dose change?

The case in front of me: nausea · four · survodutide. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
asked by b_delacroix 43k · 2.0 years ago
14 votes 5 answers38k views
What does REDEFINE-1 tell me about nausea at the 2.4 mg dose?

For reference: REDEFINE-1 · nausea · 2.4 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by samir_bennani 15k · 23 months ago
14 votes5 answers20k views
What did the placebo arm of SURMOUNT-OSA report for nausea?

What I am working with: SURMOUNT-OSA · nausea. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
asked by assay_blank 45k · 14 months ago
14 votes 4 answers13k views
Does holding at 1 mg for four weeks before escalating reduce nausea?

The case in front of me: 1 mg · four weeks · nausea. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by gunnar_isaksen 14k · 15 months ago
13 votes5 answers15k views
What is the reported incidence of nausea on a GLP-1 receptor agonist in STEP 8?

Stated plainly: nausea · a GLP-1 receptor agonist · STEP 8. I would like help reading this properly rather than being told what conclusion to reach. I have the full…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
asked by wren_calloway 23k · 19 months ago
13 votes 5 answers11k views
Does holding at 7.5 mg for four weeks before escalating reduce nausea?

The case in front of me: 7.5 mg · four weeks · nausea. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by kelvin_lam 7.6k · 6 months ago
13 votes5 answers8.5k views
What does PIONEER-4 tell me about nausea at the 25 mg dose?

Numbers first: PIONEER-4 · nausea · 25 mg. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by meniscus_film 32k · 15 months ago
13 votes0 answers8.1k views
What is the reported incidence of nausea on orforglipron in ATTAIN-1?

Setup, so nobody has to ask: nausea · orforglipron · ATTAIN-1. I have read the primary source rather than the summary, which has left me with more questions. I…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
orforglipron
orforglipron

A non-peptide, orally bioavailable small-molecule GLP-1 receptor agonist studied in the ATTAIN programme. It is not a peptide, which changes…

219 questions
asked by samir_bennani 15k · 22 months ago
11 votes 5 answers16k views
What did the placebo arm of SUSTAIN-6 report for nausea?

The particulars: SUSTAIN-6 · nausea. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably comfortable…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
asked by amara_nwachukwu 20k · 11 months ago
11 votes 2 answers9.1k views
Does nausea at week ten of dulaglutide usually resolve without a dose change?

The case in front of me: nausea · ten · dulaglutide. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
dulaglutide
dulaglutide

A once-weekly GLP-1 receptor agonist built on an Fc fusion rather than fatty-acid acylation. Use this tag for questions about the fusion-protein…

200 questions
asked by ravenna_pace 14k · 8 months ago
11 votes 5 answers7.2k views
What does SURMOUNT-5 tell me about nausea at the 10 mg dose?

The particulars: SURMOUNT-5 · nausea · 10 mg. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by orla_sheridan 18k · 4 months ago
10 votes 5 answers12k views
Does holding at 2.4 mg for twelve weeks before escalating reduce nausea?

Conditions: 2.4 mg · twelve weeks · nausea. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by p_mkhize 58k · 6 months ago
10 votes0 answers2k views
When does nausea stop being a tolerability issue and become a clinical one?

I would rather spend on verification than on volume. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow the plan…

harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
pancreatitis
pancreatitis

Acute pancreatitis as a labelled risk: background incidence, the signal in pooled trial and pharmacovigilance data, lipase interpretation, and the…

30 questions
asked by juliette_farnese 13k · 9 months ago
9 votes 5 answers5.8k views
What does STEP 5 tell me about nausea at the 2 mg dose?

For reference: STEP 5 · nausea · 2 mg. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by Dr_Priya_Raghunathan 49k · 37 days ago
8 votes 5 answers4.8k views
Does holding at 0.25 mg for two weeks before escalating reduce nausea?

Setup, so nobody has to ask: 0.25 mg · two weeks · nausea. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious.…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by marcus_thorbjorn 9.4k · 4 months ago