Endocrine changes accompanying substantial weight loss: sex hormone binding globulin, testosterone, oestradiol, cortisol and the reproductive axis, including PCOS-specific findings.
Diagnosed with PCOS at 24, now 31, BMI 34. I have been told for years that losing weight will improve my symptoms, and separately that insulin resistance is the…
Hypothyroid on 125 µg levothyroxine for six years, stable TSH around 1.4 mIU/L that whole time. Since starting tirzepatide nine months ago and losing 21 kg, my TSH…
My laboratory results are from the same laboratory each time, drawn fasting, which I gather matters. I would like help reading this properly rather than being told…
Baseline, before starting treatment: total testosterone 2.6 nmol/L, SHBG 22 nmol/L. After eight months and 16 kg of weight loss: total testosterone 1.9 nmol/L, SHBG…
My laboratory results are from the same laboratory each time, drawn fasting, which I gather matters. The failure mode I am trying to avoid is making this decision…
I have three data points across nine months, which I hope is enough to see a trend. I can parse the result. I am less sure what it licenses me to conclude. I have…
I have the full paper rather than the abstract, and the supplementary appendix. This is a planning question. I know what my options are; I do not know how to weigh…
I have the full paper rather than the abstract, and the supplementary appendix. I want to understand what this actually establishes, as opposed to what it is being…
I have three data points across nine months, which I hope is enough to see a trend. I suspect the usual explanation for this is wrong, or at least incomplete. I am…
My laboratory results are from the same laboratory each time, drawn fasting, which I gather matters. The empirical answer seems settled. The explanation does not. If…
My laboratory results are from the same laboratory each time, drawn fasting, which I gather matters. I would like help reading this properly rather than being told…
My laboratory results are from the same laboratory each time, drawn fasting, which I gather matters. This is one of those things that everyone repeats and nobody…
I have three data points across nine months, which I hope is enough to see a trend. I would like to know whether this claim survives contact with evidence. If the…
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