Page 16 of 32 · 745 questions tagged clinical-trials.
The case in front of me: ATTAIN-1 · dizziness · 24 mg. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a…
For reference: tirzepatide · mazdutide. I am trying to choose between two options that are usually discussed as though only one exists. I am not optimising for price,…
The case in front of me: retatrutide · TRIUMPH-3. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…
The particulars: oral semaglutide · 40 °C. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has tested that", I would…
I have been reading across the programmes and the A1c numbers do not line up in any way I can make sense of. SURPASS-2 reports tirzepatide lowering A1c by more than 2…
The specifics, since they change the answer: TRIUMPH-3 · early satiety · 4 mg. I have the document in front of me and I can read the numbers. What I cannot do is…
This is a question about interpretation, not about whether to act — I will take action questions elsewhere. This is one of those things that everyone repeats and…
For reference: SURMOUNT-3 · tirzepatide. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has tested that", I would…
What I have: STEP 8 · 1 mg. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s interpretation…
Setup, so nobody has to ask: constipation · semaglutide · STEP 2. I have read the primary source rather than the summary, which has left me with more questions. I…
Following on from the discussion of sampling variability: if simultaneous biopsies from the same liver disagree by a fibrosis stage in a meaningful fraction of cases,…
What I am working with: survodutide · liraglutide. These are treated as interchangeable and I do not think they are. If both are acceptable I would like to know that,…
Details up front: 15 mg · dulaglutide. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the minimum viable…
This came up because two published schedules for the same agent differ. I have read the primary source rather than the summary, which has left me with more questions.…
The particulars: REDEFINE-1 · early satiety. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…
The specifics, since they change the answer: tirzepatide · 37 °C. Somebody stated this to me confidently and I would like to check it before repeating it. I would…
Details up front: cagrilintide · room temperature. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the…
The particulars: vomiting · semaglutide · STEP 3. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is…
I have kept a symptom diary against dose dates, which turns out to have been the useful thing. The empirical answer seems settled. The explanation does not. If the…
Details up front: SURMOUNT-4 · 10 mg. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…
What I have: SURMOUNT-5 · tirzepatide. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…
Conditions: STEP 2 · semaglutide. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result, which…
I have three data points across nine months, which I hope is enough to see a trend. This should be a straightforward calculation and I keep getting two different…
Concretely: SOUL · oral semaglutide. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…