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titration

Page 15 of 19 · 456 questions tagged titration.

456 questions · sorted by votes · page 15 of 19

11 votes 5 answers21k views
What does SOUL tell me about reflux at the 14 mg dose?

What I am working with: SOUL · reflux · 14 mg. I have read the primary source rather than the summary, which has left me with more questions. I understand the…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by juan_esquivel 14k · 14 months ago
11 votes5 answers15k views
Does dizziness at week twelve of tirzepatide usually resolve without a dose change?

The case in front of me: dizziness · twelve · tirzepatide. I would like to understand the steps well enough to explain them to someone else. I have access to a…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by elke_brunner 17k · 18 months ago
11 votes 5 answers15k views
What does SURMOUNT-1 report at the 15 mg dose level?

Conditions: SURMOUNT-1 · 15 mg. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result, which I…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

764 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by coring_risk 27k · 2.4 years ago
11 votes 5 answers14k views
Does holding at 1.7 mg for three weeks before escalating reduce vomiting?

The specifics, since they change the answer: 1.7 mg · three weeks · vomiting. I would like the mechanism, because I want to be able to reason about the cases nobody…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
vomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

57 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by m_haraldsen 21k · 18 months ago
11 votes0 answers14k views
Does hair thinning at week ten of survodutide usually resolve without a dose change?

The particulars: hair thinning · ten · survodutide. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am…

hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
asked by pieter_maas 14k · 2.3 years ago
11 votes 2 answers9.1k views
Does nausea at week ten of dulaglutide usually resolve without a dose change?

The case in front of me: nausea · ten · dulaglutide. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
dulaglutide
dulaglutide

A once-weekly GLP-1 receptor agonist built on an Fc fusion rather than fatty-acid acylation. Use this tag for questions about the fusion-protein…

200 questions
asked by ravenna_pace 14k · 8 months ago
11 votes 5 answers8.1k views
Does reflux at week twelve of oral semaglutide usually resolve without a dose change?

For reference: reflux · twelve · oral semaglutide. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
oral-glp1
oral-glp1

Oral routes for GLP-1 receptor agonism: peptide formulations rescued by absorption enhancers such as SNAC, and true small molecules that need no…

219 questions
asked by mg_per_ml 15k · 19 months ago
11 votes 5 answers7.2k views
What does SURMOUNT-5 tell me about nausea at the 10 mg dose?

The particulars: SURMOUNT-5 · nausea · 10 mg. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by orla_sheridan 18k · 4 months ago
11 votes 3 answers6k views
What did FLOW do with participants who could not tolerate a step?

My records go back to the first dose with dates, so I can reconstruct the timeline exactly. I have read the primary source rather than the summary, which has left me…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questions
asked by rukhsana_iqbal 17k · 2 months ago
11 votes 5 answers4k views
Is a titration interval of twelve weeks better supported than four weeks for retatrutide?

The case in front of me: twelve weeks · retatrutide. I would rather be corrected now than propagate something wrong. I am specifically not interested in a…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
asked by p_mkhize 58k · 5 months ago
10 votes 5 answers22k views
Does injection-site erythema at week seven of oral semaglutide usually resolve without a dose change?

For reference: injection-site erythema · seven · oral semaglutide. I would like to understand the steps well enough to explain them to someone else. I have access to…

injection-site-reaction
injection-site-reaction

Local reactions: erythema, induration, pruritus and nodules. Their relationship to injection depth, diluent composition, benzyl alcohol…

49 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
oral-glp1
oral-glp1

Oral routes for GLP-1 receptor agonism: peptide formulations rescued by absorption enhancers such as SNAC, and true small molecules that need no…

219 questions
asked by Dr_Marek_Zielinski 27k · 15 months ago
10 votes 5 answers14k views
Does holding at 2.4 mg for twelve weeks before escalating reduce hair thinning?

Concretely: 2.4 mg · twelve weeks · hair thinning. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by Dr_Ingrid_Baumgartner 73k · 10 months ago
10 votes 5 answers13k views
Does injection-site erythema at week five of tirzepatide usually resolve without a dose change?

The case in front of me: injection-site erythema · five · tirzepatide. I can find plenty of assertions about this and almost no reasoning, which is usually a sign…

injection-site-reaction
injection-site-reaction

Local reactions: erythema, induration, pruritus and nodules. Their relationship to injection depth, diluent composition, benzyl alcohol…

49 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by marta_szymanska 10k · 14 months ago
10 votes 5 answers13k views
Does headache at week ten of semaglutide usually resolve without a dose change?

For reference: headache · ten · semaglutide. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the theory. What…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by lukas_sedlacek 16k · 6 months ago
10 votes 5 answers12k views
Does holding at 2.4 mg for twelve weeks before escalating reduce nausea?

Conditions: 2.4 mg · twelve weeks · nausea. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by p_mkhize 58k · 6 months ago
10 votes 5 answers11k views
If a cagrilintide dose is missed by five days, does the ladder reset?

Concretely: cagrilintide · five days. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked. Assume no…

missed-dose
missed-dose

What the label instructions for a missed weekly dose are, why they differ between agents, and what the pharmacokinetics say about drift in an…

41 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

764 questions
amylin
amylin

Amylin and its analogues, most prominently cagrilintide, as a satiety mechanism orthogonal to incretin signalling. Includes the pharmacology of…

237 questions
asked by thermal_mass 13k · 8 months ago
10 votes 5 answers8.2k views
Does vomiting at week nine of a GLP-1 receptor agonist usually resolve without a dose change?

For reference: vomiting · nine · a GLP-1 receptor agonist. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer this than…

vomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

57 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by ines_delacruz 16k · 15 months ago
10 votes5 answers7k views
Does holding at 15 mg for ten weeks before escalating reduce fatigue?

For reference: 15 mg · ten weeks · fatigue. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by bea_forsberg 11k · 15 months ago
10 votes0 answers2.8k views
What does SURMOUNT-2 tell me about constipation at the 15 mg dose?

The particulars: SURMOUNT-2 · constipation · 15 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by kofi_mensah 18k · 41 days ago
10 votes 5 answers2.2k views
Does dizziness at week seven of cagrilintide usually resolve without a dose change?

Conditions: dizziness · seven · cagrilintide. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer this than discover a…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
amylin
amylin

Amylin and its analogues, most prominently cagrilintide, as a satiety mechanism orthogonal to incretin signalling. Includes the pharmacology of…

237 questions
asked by net_peptide 12k · 37 days ago
9 votes 5 answers26k views
Is vomiting on retatrutide dose-dependent or dose-rate dependent?

Concretely: vomiting · retatrutide. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how confident…

vomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

57 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
asked by rae_oyelowo 17k · 2.2 years ago
9 votes 5 answers25k views
What does STEP 3 report at the 2.4 mg dose level?

For reference: STEP 3 · 2.4 mg. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am being…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

764 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by linnea_wahlberg 17k · 21 months ago
9 votes 5 answers19k views
What did the trials do with participants who could not tolerate a dose step?

I have read the prescribing information and it addresses the adjacent case but not this one. I can parse the result. I am less sure what it licenses me to conclude. I…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questions
asked by orla_sheridan 18k · 20 months ago
9 votes 4 answers16k views
What does TRIUMPH-1 tell me about early satiety at the 8 mg dose?

Numbers first: TRIUMPH-1 · early satiety · 8 mg. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by eighty_six_hours 20k · 2.1 years ago