Page 25 of 38 · 908 questions tagged peptide-stability.
What I am working with: 4 °C · cagrilintide. This is asserted often enough that I assumed it was established, and then I went looking for the source. I have searched…
For reference: liraglutide · ten weeks · 25 °C. I would like to define my thresholds before I have a result, for obvious reasons. I want a plan with explicit stopping…
What I have: a GLP-1 receptor agonist · sixteen weeks · room temperature. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this…
The case in front of me: deamidation · survodutide · room temperature. I would like the mechanism, because I want to be able to reason about the cases nobody has…
Numbers first: a GLP-1 receptor agonist · six weeks · 4 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would…
Setup, so nobody has to ask: tirzepatide · ten weeks · room temperature. I would like to define my thresholds before I have a result, for obvious reasons. I want a…
Numbers first: 37 °C · dulaglutide. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the evidence exists and…
Concretely: semaglutide · 8 mg/mL. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every batch, every…
The specifics, since they change the answer: deamidation · ecnoglutide · 37 °C. I would like the mechanism, because I want to be able to reason about the cases nobody…
The specifics, since they change the answer: deamidation · semaglutide · 30 °C. I understand the observation; what I do not understand is the mechanism behind it. I…
I have photographs before and after reconstitution if the visual detail matters. I want to know whether this is a real physical effect or an artefact of how it is…
Details up front: hydrolysis · dulaglutide · 30 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…
For reference: racemisation · retatrutide · VendorInvestigate. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody…
Details up front: cagrilintide · 4 °C. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a logger…
Details up front: hydrolysis · retatrutide · 40 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to…
The case in front of me: aspartimide formation · oral semaglutide · minus 20 °C. This is one of those things that everyone repeats and nobody derives. This matters…
For reference: deamidation · 30 °C. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried to reason…
Concretely: oxidation · oral semaglutide · Janoshik. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of…
Details up front: racemisation · retatrutide · 30 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…
Concretely: aspartimide formation · tirzepatide · 25 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…
Setup, so nobody has to ask: dimerisation · 2–8 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would…
My setup is a refrigerator with a logger and a small work area I wipe down, nothing more. Everything I have found on this is either a forum aside or a product page,…
What I am working with: aggregation · 37 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My background…
Stated plainly: orforglipron · 5 mg/mL. I have worked this out and I would like someone to find the error, because I suspect there is one. My working so far, for the…