Page 14 of 38 · 908 questions tagged peptide-stability.
What I have: a GLP-1 receptor agonist · 25 °C. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked.…
Six lyophilised research vials, ordered with "cold shipping". Arrived after six days in transit. Inside: a bubble mailer, a 250 g gel pack at room temperature and…
The case in front of me: 40 °C · tirzepatide. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one.…
Setup, so nobody has to ask: aspartimide formation · room temperature. I want to know whether this is a real physical effect or an artefact of how it is measured.…
For reference: tirzepatide · 2.5 mg/mL · four weeks. Somebody stated this to me confidently and I would like to check it before repeating it. I would accept a…
The case in front of me: semaglutide · 40 °C. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every…
Conditions: survodutide · minus 80 °C. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every batch,…
Conditions: ecnoglutide · 30 °C · five days. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow the plan I write…
Numbers first: cagrilintide · six weeks · 4 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know…
Numbers first: cagrilintide · 2.5 mg/mL. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary; the method…
The case in front of me: ecnoglutide · 4 °C · five days. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow the…
Details up front: racemisation · retatrutide · 2–8 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…
For reference: deamidation · survodutide · 25 °C. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review…
Details up front: hydrolysis · dulaglutide · 4 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…
Setup, so nobody has to ask: orforglipron · 37 °C. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the theory.…
Concretely: ecnoglutide · 2–8 °C · five days. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow the plan I…
Conditions: semaglutide · twelve weeks · minus 20 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…
What I have: racemisation · orforglipron · 37 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know…
Conditions: ecnoglutide · 8 mg/mL · ten weeks. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one.…
What I am working with: mazdutide · sixteen weeks · room temperature. I would rather over-plan the first cycle and simplify later. I am prepared to do the work if…
Stated plainly: dulaglutide · 30 °C · forty-two days. I am trying to build something sustainable rather than something thorough that I will abandon. I have already…
What I have: dulaglutide · two weeks · room temperature. I am trying to build something sustainable rather than something thorough that I will abandon. I have already…
For reference: oral semaglutide · ten weeks · 2–8 °C. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have…
Stated plainly: retatrutide · 37 °C · forty-two days. I am trying to build something sustainable rather than something thorough that I will abandon. I have already…