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hair-loss

Page 2 of 3 · 50 questions tagged hair-loss.

50 questions · sorted by votes · page 2 of 3

20 votes 5 answers28k views
Does holding at 1 mg for two weeks before escalating reduce hair thinning?

Stated plainly: 1 mg · two weeks · hair thinning. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by g_paskevicius 60k · 13 months ago
19 votes 5 answers16k views
Does holding at 0.25 mg for twelve weeks before escalating reduce hair thinning?

Concretely: 0.25 mg · twelve weeks · hair thinning. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by void_volume 9.5k · 10 months ago
18 votes2 answers8.4k views
What does PIONEER-4 tell me about hair thinning at the 25 mg dose?

Numbers first: PIONEER-4 · hair thinning · 25 mg. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by pip_okonjo 13k · 14 months ago
18 votes 3 answers3k views
What did the placebo arm of REDEFINE-1 report for hair thinning?

Numbers first: REDEFINE-1 · hair thinning. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
asked by Dr_Signe_Baldursdottir 29k · 2 months ago
17 votes5 answers20k views
What did the placebo arm of FLOW report for hair thinning?

Stated plainly: FLOW · hair thinning. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably comfortable…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
asked by birk_nordahl 16k · 20 months ago
16 votes0 answers2.6k views
Does hair thinning at week eight of orforglipron usually resolve without a dose change?

The case in front of me: hair thinning · eight · orforglipron. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have…

hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
orforglipron
orforglipron

A non-peptide, orally bioavailable small-molecule GLP-1 receptor agonist studied in the ATTAIN programme. It is not a peptide, which changes…

219 questions
asked by gel_pack_warm 13k · 3 months ago
15 votes 5 answers21k views
Does hair thinning at week six of dulaglutide usually resolve without a dose change?

The particulars: hair thinning · six · dulaglutide. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already made one…

hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
dulaglutide
dulaglutide

A once-weekly GLP-1 receptor agonist built on an Fc fusion rather than fatty-acid acylation. Use this tag for questions about the fusion-protein…

200 questions
asked by ahmed_zerouali 15k · 13 months ago
14 votes4 answers11k views
What does STEP 2 tell me about hair thinning at the 1 mg dose?

For reference: STEP 2 · hair thinning · 1 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by t_oyelaran 79k · 14 months ago
13 votes 5 answers24k views
Is hair thinning on liraglutide dose-dependent or dose-rate dependent?

Concretely: hair thinning · liraglutide. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is an…

hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
liraglutide
liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

235 questions
asked by anja_hellstrom 13k · 2.0 years ago
13 votes 5 answers18k views
Is hair thinning on a GLP-1 receptor agonist dose-dependent or dose-rate dependent?

Setup, so nobody has to ask: hair thinning · a GLP-1 receptor agonist. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me…

hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by anouk_desmet 16k · 19 months ago
12 votes5 answers12k views
What does SUSTAIN-6 tell me about hair thinning at the 1 mg dose?

Details up front: SUSTAIN-6 · hair thinning · 1 mg. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by kirsi_lahtinen 25k · 13 months ago
12 votes 5 answers10k views
What does STEP 8 tell me about hair thinning at the 1 mg dose?

Numbers first: STEP 8 · hair thinning · 1 mg. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by felix_araya 6.8k · 2.0 years ago
12 votes 5 answers6.5k views
Does holding at 7.5 mg for eight weeks before escalating reduce hair thinning?

Stated plainly: 7.5 mg · eight weeks · hair thinning. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by net_peptide 12k · 4 months ago
12 votes0 answers6.4k views
What is the reported incidence of hair thinning on semaglutide in STEP 2?

Setup, so nobody has to ask: hair thinning · semaglutide · STEP 2. I would like help reading this properly rather than being told what conclusion to reach. I have the…

hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by eoin_mcgarry 18k · 10 months ago
11 votes0 answers14k views
Does hair thinning at week ten of survodutide usually resolve without a dose change?

The particulars: hair thinning · ten · survodutide. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am…

hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
asked by pieter_maas 14k · 2.3 years ago
10 votes 5 answers14k views
Does holding at 2.4 mg for twelve weeks before escalating reduce hair thinning?

Concretely: 2.4 mg · twelve weeks · hair thinning. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by Dr_Ingrid_Baumgartner 73k · 10 months ago
9 votes5 answers10k views
What does REDEFINE-1 tell me about hair thinning at the 2.4 mg dose?

What I have: REDEFINE-1 · hair thinning · 2.4 mg. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by ruaidhri_o_shea 25k · 2.3 years ago
9 votes 5 answers6.6k views
What does SURPASS-3 tell me about hair thinning at the 5 mg dose?

For reference: SURPASS-3 · hair thinning · 5 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by cap_the_luer 14k · 3 months ago
8 votes5 answers18k views
What did the placebo arm of SURPASS-3 report for hair thinning?

For reference: SURPASS-3 · hair thinning. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
asked by mass_shift_18 9.7k · 16 months ago
8 votes 5 answers16k views
Does hair thinning at week two of orforglipron usually resolve without a dose change?

For reference: hair thinning · two · orforglipron. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of…

hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
orforglipron
orforglipron

A non-peptide, orally bioavailable small-molecule GLP-1 receptor agonist studied in the ATTAIN programme. It is not a peptide, which changes…

219 questions
asked by coring_risk 27k · 20 months ago
6 votes 5 answers24k views
Is a micronutrient panel worth drawing after six months of low intake?

I have three DEXA scans on the same scanner at twelve-week intervals, fasted, same time of day. This is a planning question. I know what my options are; I do not know…

nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questions
bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

296 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
asked by eoin_mcgarry 18k · 2.2 years ago
6 votes0 answers4.5k views
What does ESSENCE tell me about hair thinning at the 2 mg dose?

What I have: ESSENCE · hair thinning · 2 mg. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by sinead_gaffney 28k · 2.1 years ago
5 votes 5 answers5.2k views
What did the placebo arm of SURMOUNT-OSA report for hair thinning?

What I am working with: SURMOUNT-OSA · hair thinning. This is presented as though it settles something, and I am not convinced it does. I have two documents that…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
asked by ten_mg_vial 31k · 8 months ago
5 votes 5 answers3.8k views
Is hair thinning on oral semaglutide dose-dependent or dose-rate dependent?

Concretely: hair thinning · oral semaglutide. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question…

hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

50 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
oral-glp1
oral-glp1

Oral routes for GLP-1 receptor agonism: peptide formulations rescued by absorption enhancers such as SNAC, and true small molecules that need no…

219 questions
asked by mala_venkatesh 22k · 3 months ago