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glucagon-receptor

Glucagon receptor agonism as a deliberate component of dual and tri-agonists: what it adds in energy expenditure and hepatic fat mobilisation, and what it costs in glycaemic control and heart rate.

8 questions · sorted by votes

30 votes 3 answers13k views
What does adding glucagon receptor agonism actually buy, and what does it cost you?

I am trying to understand the logic of putting glucagon receptor agonism into a weight-loss molecule, because on the face of it it sounds like a mistake. Glucagon…

retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
glucagon-receptor
glucagon-receptor

Glucagon receptor agonism as a deliberate component of dual and tri-agonists: what it adds in energy expenditure and hepatic fat mobilisation, and…

8 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
asked by s_bhattacharya 31k · 20 months ago
23 votes 3 answers6.4k views
What GLP-1 to glucagon potency ratio do the published dual agonists use?

I would like to know how much of this is established and how much is a reasonable story. I have the document in front of me and I can read the numbers. What I cannot…

glucagon-receptor
glucagon-receptor

Glucagon receptor agonism as a deliberate component of dual and tri-agonists: what it adds in energy expenditure and hepatic fat mobilisation, and…

8 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
mazdutide
mazdutide

A GLP-1 and glucagon receptor dual agonist developed primarily in China, with a distinct dose range and a fast-moving publication record.…

237 questions
asked by ilaria_bertone 33k · 4 months ago
21 votes5 answers17k views
Why does glucagon co-agonism raise heart rate more than a pure GLP-1?

I would like to know how much of this is established and how much is a reasonable story. I suspect the usual explanation for this is wrong, or at least incomplete. I…

glucagon-receptor
glucagon-receptor

Glucagon receptor agonism as a deliberate component of dual and tri-agonists: what it adds in energy expenditure and hepatic fat mobilisation, and…

8 questions
cardiovascular
cardiovascular

Cardiovascular outcomes: the SELECT major-adverse-event result, SOUL, SUSTAIN 6 and REWIND, how to convert a hazard ratio into an absolute risk…

68 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

132 questions
asked by shear_at_the_front 17k · 21 months ago
21 votes5 answers15k views
Is hepatic fat mobilisation attributable to the glucagon arm specifically?

This matters because it predicts what a related molecule should do. This is one of those things that everyone repeats and nobody derives. This matters practically,…

glucagon-receptor
glucagon-receptor

Glucagon receptor agonism as a deliberate component of dual and tri-agonists: what it adds in energy expenditure and hepatic fat mobilisation, and…

8 questions
mash
mash

Metabolic dysfunction-associated steatohepatitis: histological endpoints, resolution without worsening fibrosis, fibrosis improvement by stage,…

56 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
asked by kirsi_lahtinen 25k · 4 months ago
20 votes 5 answers20k views
Does glucagon receptor agonism cost glycaemic control at the top doses?

This matters because it predicts what a related molecule should do. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me…

glucagon-receptor
glucagon-receptor

Glucagon receptor agonism as a deliberate component of dual and tri-agonists: what it adds in energy expenditure and hepatic fat mobilisation, and…

8 questions
t2dm
t2dm

Type 2 diabetes: glycaemic endpoints, the SURPASS and SUSTAIN programmes, dose ranges licensed for diabetes versus obesity, and interaction with…

22 questions
a1c
a1c

Glycated haemoglobin as a ninety-day glycaemic average: what a change of half a point means, why it lags, and the conditions under which it…

122 questions
asked by ahmed_zerouali 15k · 23 months ago
7 votes0 answers1.6k views
How would a trial separate a glucagon effect from a weight-loss effect?

I would like to know how much of this is established and how much is a reasonable story. I can find plenty of assertions about this and almost no reasoning, which is…

glucagon-receptor
glucagon-receptor

Glucagon receptor agonism as a deliberate component of dual and tri-agonists: what it adds in energy expenditure and hepatic fat mobilisation, and…

8 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
asked by Dr_Lena_Ostrowska 38k · 4 months ago
6 votes5 answers20k views
What does the glucagon arm of a tri-agonist add, and what does it cost?

I would like to know how much of this is established and how much is a reasonable story. I have used one of these for a while and I am considering switching, which…

glucagon-receptor
glucagon-receptor

Glucagon receptor agonism as a deliberate component of dual and tri-agonists: what it adds in energy expenditure and hepatic fat mobilisation, and…

8 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
asked by h_villanueva 70k · 2.3 years ago
2 votes 5 answers17k views
How much of the energy-expenditure claim for glucagon agonism is human data?

This matters because it predicts what a related molecule should do. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if…

glucagon-receptor
glucagon-receptor

Glucagon receptor agonism as a deliberate component of dual and tri-agonists: what it adds in energy expenditure and hepatic fat mobilisation, and…

8 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
asked by coldbox9 41k · 2.1 years ago
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