PeptideStack
5.2kquestions
20kanswers
220users

food-noise

The reduction in intrusive, appetitive thinking about food that most people on the class describe. Its likely basis in central GLP-1R signalling, why it is not the same thing as nausea-driven aversion, and what its return may signal.

8 questions · sorted by votes

53 votes 3 answers33k views
What is "food noise" mechanistically, and which brain regions is the drug actually acting on?

The phrase "food noise" is used constantly and I have never seen it defined precisely. My own experience of it was extremely specific and I would like to know what it…

food-noise
food-noise

The reduction in intrusive, appetitive thinking about food that most people on the class describe. Its likely basis in central GLP-1R signalling,…

8 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

132 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by forty_units 16k · 22 months ago
45 votes3 answers17k views
Why did my interest in alcohol disappear alongside the food noise, and what does that overlap tell us?

I started semaglutide for weight and something I did not expect happened: I stopped drinking, more or less by accident. I was on four or five drinks most evenings for…

food-noise
food-noise

The reduction in intrusive, appetitive thinking about food that most people on the class describe. Its likely basis in central GLP-1R signalling,…

8 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

132 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
asked by mala_venkatesh 22k · 8 months ago
45 votes 3 answers17k views
How do I tell whether I am eating less because of reduced reward drive or because I am subtly nauseated?

Eight weeks in on tirzepatide and I cannot work out which of two things is happening, and I think it matters. Version A: my appetite drive is genuinely reduced, food…

food-noise
food-noise

The reduction in intrusive, appetitive thinking about food that most people on the class describe. Its likely basis in central GLP-1R signalling,…

8 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

132 questions
asked by pierce_count 24k · 15 months ago
40 votes3 answers15k views
Food noise came back at month seven. Is that tolerance, and does it mean the dose has to go up?

Months two through six were the quietest my head has been about food since childhood. Around month seven it started coming back, and now at month nine it is maybe 40%…

food-noise
food-noise

The reduction in intrusive, appetitive thinking about food that most people on the class describe. Its likely basis in central GLP-1R signalling,…

8 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
plateau
plateau

A stall in progress: distinguishing adaptive thermogenesis from measurement error from adherence drift, how long to observe before changing…

36 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

132 questions
asked by ivo_paunovic 16k · 2 months ago
20 votes 5 answers4.2k views
If food noise returns, is that tolerance or a plateau?

Scale weight, waist circumference and a repetition maximum, all logged weekly. I want to know whether this is a real physical effect or an artefact of how it is…

food-noise
food-noise

The reduction in intrusive, appetitive thinking about food that most people on the class describe. Its likely basis in central GLP-1R signalling,…

8 questions
plateau
plateau

A stall in progress: distinguishing adaptive thermogenesis from measurement error from adherence drift, how long to observe before changing…

36 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

132 questions
asked by label_claim 30k · 3 months ago
13 votes2 answers14k views
Is early satiety a side effect or the mechanism working?

No other medication changes, no dietary changes, nothing else obviously confounding. I want to know whether this is a real physical effect or an artefact of how it is…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

132 questions
food-noise
food-noise

The reduction in intrusive, appetitive thinking about food that most people on the class describe. Its likely basis in central GLP-1R signalling,…

8 questions
asked by otto_brenner 12k · 12 months ago
10 votes3 answers12k views
How do I hit a protein target when appetite suppression is severe?

I would like to know what to measure as much as what to do. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already…

protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

60 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questions
food-noise
food-noise

The reduction in intrusive, appetitive thinking about food that most people on the class describe. Its likely basis in central GLP-1R signalling,…

8 questions
asked by unit_math 6.2k · 18 months ago
5 votes 5 answers2.9k views
How much of the effect is delayed gastric emptying versus central satiety?

This matters because it predicts what a related molecule should do. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

132 questions
food-noise
food-noise

The reduction in intrusive, appetitive thinking about food that most people on the class describe. Its likely basis in central GLP-1R signalling,…

8 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questions
asked by Dr_Colm_Fitzhenry 69k · 6 months ago
Sponsored

PeptideMeter - Independent Peptide Analytics

Aggregated, published test results and vendor ratings built from submitted batches. Methodology stated, dataset browsable, no listing fees.

Browse results