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fatigue

Page 4 of 4 · 78 questions tagged fatigue.

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78 questions · sorted by votes · page 4 of 4

4 votes 5 answers4.2k views
Does fatigue at week five of cagrilintide usually resolve without a dose change?

Conditions: fatigue · five · cagrilintide. I have read the obvious sources and they disagree with each other, so I would rather ask people who have actually done…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questionstitration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsamylin
amylin

Amylin and its analogues, most prominently cagrilintide, as a satiety mechanism orthogonal to incretin signalling. Includes the pharmacology of…

237 questionsasked by anja_hellstrom 13k · 7 months ago
3 votes 5 answers19k views
How do I tell vomiting from an energy deficit on 1,200 kcal a day?

For reference: vomiting · 1,200 kcal. Something has gone wrong and I would like to know how badly before I decide what to do. Nothing else in the setup changed, which…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questionsnutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questionselectrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

72 questionsasked by ekaterina_volk 21k · 18 months ago
3 votes5 answers15k views
What is the reported incidence of fatigue on tirzepatide in SURMOUNT-OSA?

Stated plainly: fatigue · tirzepatide · SURMOUNT-OSA. This is presented as though it settles something, and I am not convinced it does. I have two documents that…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questionsclinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questionstirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questionsasked by mg_per_ml 15k · 16 months ago
3 votes 5 answers1.6k views
Does holding at 10 mg for ten weeks before escalating reduce fatigue?

The particulars: 10 mg · ten weeks · fatigue. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsfatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questionsdose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questionsasked by thermal_mass 13k · 17 days ago
2 votes 5 answers8.2k views
How do I tell nausea from an energy deficit on 1,400 kcal a day?

Conditions: nausea · 1,400 kcal. I think I have a problem. I am not yet sure whether it is a real problem or a measurement artefact. I want to know whether this is…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questionsnutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questionselectrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

72 questionsasked by sasha_ferreira 9.4k · 23 months ago
2 votes4 answers3.2k views
How do I tell injection-site erythema from an energy deficit on 800 kcal a day?

The specifics, since they change the answer: injection-site erythema · 800 kcal. An unexpected observation, and I would like a differential rather than reassurance.…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questionsnutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questionselectrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

72 questionsasked by aine_mulcahy 28k · 5 days ago