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dose-escalation

Page 5 of 5 · 103 questions tagged dose-escalation.

103 questions · sorted by votes · page 5 of 5

5 votes 5 answers9.4k views
Does holding at 0.25 mg for four weeks before escalating reduce early satiety?

Conditions: 0.25 mg · four weeks · early satiety. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by assay_blank 45k · 2.2 years ago
4 votes 2 answers12k views
Does a plateau mean I need a dose step, or that I need to wait?

The trend is what I care about; individual weeks are obviously noise. This is a planning question. I know what my options are; I do not know how to weigh them. What I…

plateau
plateau

A stall in progress: distinguishing adaptive thermogenesis from measurement error from adherence drift, how long to observe before changing…

36 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

54 questions
asked by cap_the_luer 14k · 20 months ago
4 votes 4 answers5.2k views
Does holding at 0.25 mg for twelve weeks before escalating reduce nausea?

Conditions: 0.25 mg · twelve weeks · nausea. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by halvard_ness 69k · 14 months ago
3 votes 5 answers1.6k views
Does holding at 10 mg for ten weeks before escalating reduce fatigue?

The particulars: 10 mg · ten weeks · fatigue. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by thermal_mass 13k · 17 days ago
2 votes 1 answer1.9k views
Does holding at 10 mg for three weeks before escalating reduce vomiting?

For reference: 10 mg · three weeks · vomiting. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
vomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

57 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by tandem_gradient 61k · 6 months ago
2 votes0 answers896 views
Does holding at 12.5 mg for eight weeks before escalating reduce nausea?

What I am working with: 12.5 mg · eight weeks · nausea. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

55 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by sample_id 17k · 12 months ago
1 vote5 answers3.9k views
How predictive is a Phase 2 dose-response for a Phase 3 result?

The clinician who ordered the panel was not concerned; I would still like to understand it. This is one of those things that everyone repeats and nobody derives. This…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by rosa_mendieta 8k · 4 months ago