PeptideStack
5.2kquestions
20kanswers
220users

constipation

Page 2 of 3 · 55 questions tagged constipation.

55 questions · sorted by votes · page 2 of 3

22 votes4 answers8.7k views
What does PIONEER-1 tell me about constipation at the 7 mg dose?

Details up front: PIONEER-1 · constipation · 7 mg. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by net_peptide 12k · 39 days ago
22 votes 5 answers6.6k views
Does holding at 0.25 mg for four weeks before escalating reduce constipation?

Conditions: 0.25 mg · four weeks · constipation. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by Dr_Lena_Ostrowska 38k · 4 months ago
21 votes 5 answers24k views
What did the placebo arm of FLOW report for constipation?

What I am working with: FLOW · constipation. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
asked by syringe_ninety 12k · 2.1 years ago
21 votes5 answers14k views
Does holding at 12.5 mg for four weeks before escalating reduce constipation?

The case in front of me: 12.5 mg · four weeks · constipation. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by bufferline42 30k · 18 months ago
20 votes 3 answers13k views
Does fibre help or worsen constipation at very low intake?

I have kept a symptom diary against dose dates, which turns out to have been the useful thing. Both of these get recommended confidently by different people, which…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questions
asked by seven_day_half 31k · 9 months ago
20 votes0 answers5.6k views
What is the reported incidence of constipation on semaglutide in STEP 2?

Setup, so nobody has to ask: constipation · semaglutide · STEP 2. I have read the primary source rather than the summary, which has left me with more questions. I…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by fiadh_cronin 58k · 11 months ago
18 votes 5 answers29k views
Does holding at 0.25 mg for two weeks before escalating reduce constipation?

Stated plainly: 0.25 mg · two weeks · constipation. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by tare_weight 60k · 16 months ago
18 votes5 answers19k views
Is constipation on liraglutide dose-dependent or dose-rate dependent?

What I have: constipation · liraglutide. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically,…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
liraglutide
liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

235 questions
asked by Dr_Fatima_Belkacem 18k · 2.1 years ago
18 votes 5 answers7.7k views
Is constipation on tirzepatide dose-dependent or dose-rate dependent?

What I have: constipation · tirzepatide. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically,…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by Dr_Hanne_Solberg 36k · 5 months ago
17 votes 5 answers40k views
What did the placebo arm of SOUL report for constipation?

What I have: SOUL · constipation. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am being…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
asked by second_lot 9.4k · 23 months ago
17 votes0 answers7.6k views
Does constipation at week ten of survodutide usually resolve without a dose change?

The case in front of me: constipation · ten · survodutide. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
asked by kwn_analytical 147k · 4 months ago
16 votes1 answer6.6k views
What does SOUL tell me about constipation at the 7 mg dose?

What I have: SOUL · constipation · 7 mg. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by Dr_Otto_Lindqvist 72k · 7 months ago
15 votes 5 answers13k views
Is constipation on a GLP-1 receptor agonist dose-dependent or dose-rate dependent?

Stated plainly: constipation · a GLP-1 receptor agonist. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by bea_castellanos 24k · 2.1 years ago
14 votes0 answers2.3k views
What did the placebo arm of STEP 2 report for constipation?

The particulars: STEP 2 · constipation. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably comfortable…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
asked by gel_pack_warm 13k · 5 months ago
12 votes 4 answers6.4k views
What did the placebo arm of TRIUMPH-1 report for constipation?

What I have: TRIUMPH-1 · constipation. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
asked by per_haugen 13k · 8 months ago
11 votes 5 answers27k views
Does constipation at week ten of dulaglutide usually resolve without a dose change?

The particulars: constipation · ten · dulaglutide. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
dulaglutide
dulaglutide

A once-weekly GLP-1 receptor agonist built on an Fc fusion rather than fatty-acid acylation. Use this tag for questions about the fusion-protein…

200 questions
asked by rukhsana_iqbal 17k · 20 months ago
11 votes 5 answers26k views
What did the placebo arm of SURMOUNT-1 report for constipation?

The particulars: SURMOUNT-1 · constipation. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
asked by dermot_kiely 12k · 17 months ago
11 votes 5 answers13k views
What is the reported incidence of constipation on semaglutide in FLOW?

Setup, so nobody has to ask: constipation · semaglutide · FLOW. I have read the primary source rather than the summary, which has left me with more questions. I…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by rhian_prydderch 23k · 2.2 years ago
10 votes 5 answers24k views
What is the reported incidence of constipation on a GLP-1 receptor agonist in SURPASS-3?

What I am working with: constipation · a GLP-1 receptor agonist · SURPASS-3. I have read the primary source rather than the summary, which has left me with more…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
asked by eoin_mcgarry 18k · 20 months ago
10 votes0 answers2.8k views
What does SURMOUNT-2 tell me about constipation at the 15 mg dose?

The particulars: SURMOUNT-2 · constipation · 15 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by kofi_mensah 18k · 41 days ago
9 votes 5 answers30k views
What did the placebo arm of STEP 1 report for constipation?

Details up front: STEP 1 · constipation. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
asked by greta_holzmann 23k · 2.3 years ago
8 votes 5 answers32k views
Does constipation at week eight of semaglutide usually resolve without a dose change?

For reference: constipation · eight · semaglutide. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by mateo_iglesias 12k · 2.2 years ago
8 votes5 answers19k views
What does SOUL tell me about constipation at the 14 mg dose?

The specifics, since they change the answer: SOUL · constipation · 14 mg. I want to understand what this actually establishes, as opposed to what it is being used to…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by helena_vidmar 8.5k · 15 months ago
8 votes 5 answers14k views
What is the reported incidence of constipation on semaglutide in ESSENCE?

Stated plainly: constipation · semaglutide · ESSENCE. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by ben_akintola 10k · 23 months ago