PeptideStack
5.2kquestions
20kanswers
220users

vomiting

Page 3 of 3 · 57 questions tagged vomiting.

NewestActiveVotesUnanswered

57 questions · sorted by votes · page 3 of 3

5 votes0 answers3.8k views
What does SURMOUNT-3 tell me about vomiting at the 10 mg dose?

Concretely: SURMOUNT-3 · vomiting · 10 mg. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questionsvomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

57 questionstitration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsasked by tyndall_haze 38k · 22 months ago
4 votes 5 answers8.7k views
What does SURMOUNT-2 tell me about vomiting at the 10 mg dose?

Setup, so nobody has to ask: SURMOUNT-2 · vomiting · 10 mg. I would like help reading this properly rather than being told what conclusion to reach. I have the full…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questionsvomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

57 questionstitration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsasked by coring_risk 27k · 9 months ago
4 votes0 answers7k views
What is the reported incidence of vomiting on tirzepatide in SURMOUNT-OSA?

The particulars: vomiting · tirzepatide · SURMOUNT-OSA. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern…

vomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

57 questionsclinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questionstirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questionsasked by mala_venkatesh 22k · 23 months ago
4 votes3 answers3k views
What does STEP 2 tell me about vomiting at the 1 mg dose?

Concretely: STEP 2 · vomiting · 1 mg. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result,…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questionsvomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

57 questionstitration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsasked by drawn_and_capped 12k · 10 months ago
3 votes 5 answers12k views
Does vomiting at week twelve of a GLP-1 receptor agonist usually resolve without a dose change?

The particulars: vomiting · twelve · a GLP-1 receptor agonist. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer this…

vomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

57 questionstitration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsasked by two_point_four 8.9k · 17 months ago
2 votes5 answers17k views
What does STEP 3 tell me about vomiting at the 2 mg dose?

Conditions: STEP 3 · vomiting · 2 mg. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result,…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questionsvomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

57 questionstitration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsasked by dead_volume 56k · 2.0 years ago
2 votes5 answers12k views
What did the placebo arm of ATTAIN-1 report for vomiting?

Concretely: ATTAIN-1 · vomiting. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result, which I…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questionsvomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

57 questionsasked by loss_on_drying 40k · 16 months ago
2 votes 5 answers10k views
What did the placebo arm of SURPASS-3 report for vomiting?

Stated plainly: SURPASS-3 · vomiting. I would like help reading this properly rather than being told what conclusion to reach. I have the full report including the…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questionsvomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

57 questionsasked by lukas_sedlacek 16k · 18 months ago
2 votes 1 answer1.9k views
Does holding at 10 mg for three weeks before escalating reduce vomiting?

For reference: 10 mg · three weeks · vomiting. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsvomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

57 questionsdose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questionsasked by tandem_gradient 61k · 6 months ago