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storage

Page 27 of 30 · 701 questions tagged storage.

701 questions · sorted by votes · page 27 of 30

6 votes0 answers2.9k views
What happens to oral semaglutide after three weeks at 30 °C in solution?

The specifics, since they change the answer: oral semaglutide · three weeks · 30 °C. I understand the observation; what I do not understand is the mechanism behind…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
oral-glp1
oral-glp1

Oral routes for GLP-1 receptor agonism: peptide formulations rescued by absorption enhancers such as SNAC, and true small molecules that need no…

219 questions
asked by drawn_and_capped 12k · 22 months ago
6 votes0 answers2.8k views
Does fibrillation dominate for ecnoglutide held at 37 °C?

For reference: fibrillation · ecnoglutide · 37 °C. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
ecnoglutide
ecnoglutide

A long-acting GLP-1 receptor agonist with a cAMP-biased signalling profile. A niche tag, mostly used for mechanism questions about biased agonism…

223 questions
asked by orla_sheridan 18k · 18 months ago
6 votes 4 answers2.1k views
What happens to retatrutide after eight weeks at 25 °C in solution?

Setup, so nobody has to ask: retatrutide · eight weeks · 25 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
asked by lane_transit 60k · 22 days ago
6 votes1 answer1.6k views
Is there any published stability data for tirzepatide at 2–8 °C?

The specifics, since they change the answer: tirzepatide · 2–8 °C. I would like to know whether this claim survives contact with evidence. If the answer is "nobody…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by bea_castellanos 24k · 6 months ago
5 votes4 answers18k views
Does dimerisation dominate for cagrilintide held at minus 80 °C?

What I am working with: dimerisation · cagrilintide · minus 80 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
amylin
amylin

Amylin and its analogues, most prominently cagrilintide, as a satiety mechanism orthogonal to incretin signalling. Includes the pharmacology of…

237 questions
asked by dmitri_savchuk 27k · 2.3 years ago
5 votes5 answers16k views
Is a domestic freezer good enough for storing reconstituted tirzepatide?

Stated plainly: a domestic freezer · tirzepatide. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow the plan I…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by ines_brandt 113k · 23 months ago
5 votes 5 answers15k views
Is 25 °C an acceptable storage condition for lyophilised liraglutide?

The case in front of me: 25 °C · liraglutide. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one.…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
liraglutide
liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

235 questions
asked by pip_okonjo 13k · 2.0 years ago
5 votes5 answers15k views
Does a phase-change pack hold a dulaglutide shipment for fourteen days in transit?

Details up front: dulaglutide · fourteen days. I have worked this out and I would like someone to find the error, because I suspect there is one. My working so far,…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
dulaglutide
dulaglutide

A once-weekly GLP-1 receptor agonist built on an Fc fusion rather than fatty-acid acylation. Use this tag for questions about the fusion-protein…

200 questions
asked by gradient_slope 46k · 17 months ago
5 votes 5 answers13k views
Does survodutide adsorb measurably to the vial wall at 3.33 mg/mL?

Concretely: survodutide · 3.33 mg/mL. Please show the division. I want to check my own against yours. I would like the general form as well as the specific number, so…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

476 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
asked by fresh_bac 9.7k · 17 months ago
5 votes 5 answers12k views
Is there any published stability data for orforglipron at minus 80 °C?

What I am working with: orforglipron · minus 80 °C. This is asserted often enough that I assumed it was established, and then I went looking for the source. I have…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
orforglipron
orforglipron

A non-peptide, orally bioavailable small-molecule GLP-1 receptor agonist studied in the ATTAIN programme. It is not a peptide, which changes…

219 questions
asked by marcus_thorbjorn 9.4k · 17 months ago
5 votes 5 answers10k views
How many freeze-thaw cycles will dulaglutide at 3.33 mg/mL tolerate?

What I am working with: dulaglutide · 3.33 mg/mL. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the theory.…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

57 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
dulaglutide
dulaglutide

A once-weekly GLP-1 receptor agonist built on an Fc fusion rather than fatty-acid acylation. Use this tag for questions about the fusion-protein…

200 questions
asked by area_percent 9.9k · 7 months ago
5 votes 5 answers7.8k views
Is an insulated cool box good enough for storing reconstituted oral semaglutide?

Setup, so nobody has to ask: an insulated cool box · oral semaglutide. The failure mode I am trying to avoid is making this decision emotionally. I have twelve months…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
oral-glp1
oral-glp1

Oral routes for GLP-1 receptor agonism: peptide formulations rescued by absorption enhancers such as SNAC, and true small molecules that need no…

219 questions
asked by j_wierzbicki 69k · 18 months ago
5 votes5 answers7.4k views
Is there any published stability data for semaglutide at minus 80 °C?

Concretely: semaglutide · minus 80 °C. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and monographs…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by fiadh_cronin 58k · 2.0 years ago
5 votes 5 answers5.1k views
How long does a GLP-1 receptor agonist stay within specification at 30 °C once reconstituted?

Numbers first: a GLP-1 receptor agonist · 30 °C. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked.…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
asked by mateo_iglesias 12k · 3 months ago
5 votes5 answers4.9k views
Is minus 80 °C an acceptable storage condition for lyophilised semaglutide?

For reference: minus 80 °C · semaglutide. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has tested that", I would…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by klara_novotna 19k · 12 months ago
5 votes0 answers4.4k views
How long does retatrutide stay within specification at 30 °C once reconstituted?

Stated plainly: retatrutide · 30 °C. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the theory. What I have…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
asked by loss_on_drying 40k · 2.1 years ago
5 votes5 answers4.1k views
Does mazdutide adsorb measurably to the vial wall at 4 mg/mL?

What I have: mazdutide · 4 mg/mL. I can do the algebra. I am not confident about the conversion factors. If there is a standard way to lay this out, I would rather…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

476 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
mazdutide
mazdutide

A GLP-1 and glucagon receptor dual agonist developed primarily in China, with a distinct dose range and a fast-moving publication record.…

237 questions
asked by kofi_mensah 18k · 10 months ago
5 votes0 answers2.5k views
How many freeze-thaw cycles will retatrutide at 8 mg/mL tolerate?

What I am working with: retatrutide · 8 mg/mL. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the theory.…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

57 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
asked by liam_bracken 6.9k · 2.0 years ago
5 votes0 answers1.7k views
What happens to a GLP-1 receptor agonist after sixteen weeks at minus 80 °C in solution?

Numbers first: a GLP-1 receptor agonist · sixteen weeks · minus 80 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
asked by claudia_ferrante 22k · 2 months ago
5 votes0 answers798 views
Is a wine cooler good enough for storing reconstituted cagrilintide?

The particulars: a wine cooler · cagrilintide. I would like to set this up properly once, rather than adjust it repeatedly. My budget is real but not tight, and my…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
amylin
amylin

Amylin and its analogues, most prominently cagrilintide, as a satiety mechanism orthogonal to incretin signalling. Includes the pharmacology of…

237 questions
asked by rukhsana_iqbal 17k · 4 months ago
4 votes5 answers16k views
Does oxidation dominate for liraglutide held at 2–8 °C?

Conditions: oxidation · liraglutide · 2–8 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically,…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
liraglutide
liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

235 questions
asked by ilaria_bertone 33k · 14 months ago
4 votes 5 answers9.3k views
What happens to retatrutide after two weeks at minus 20 °C in solution?

Stated plainly: retatrutide · two weeks · minus 20 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
asked by claudia_ferrante 22k · 8 months ago
4 votes 5 answers8.7k views
How long does mazdutide stay within specification at 2–8 °C once reconstituted?

Numbers first: mazdutide · 2–8 °C. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a logger and…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
mazdutide
mazdutide

A GLP-1 and glucagon receptor dual agonist developed primarily in China, with a distinct dose range and a fast-moving publication record.…

237 questions
asked by lyoph_cake 78k · 6 months ago
4 votes 4 answers8.3k views
Why does hydrolysis accelerate at minus 80 °C rather than proceeding linearly?

Details up front: hydrolysis · minus 80 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
asked by aine_mulcahy 28k · 2.3 years ago