Page 3 of 32 · 745 questions tagged clinical-trials.
I am on tirzepatide 10 mg and have been flat for seven weeks. The reflex answer everywhere is "titrate up", and 12.5 and 15 mg exist, so the option is there. But I…
I am trying to calibrate how likely it is that GI side effects end up being the reason someone stops, as opposed to being an unpleasant thing they get through. The…
Setup, so nobody has to ask: hair thinning · oral semaglutide · PIONEER-1. I have read the primary source rather than the summary, which has left me with more…
The receptor pharmacology I can follow; the in vivo translation is where I lose the thread. I would like help reading this properly rather than being told what…
Stated plainly: semaglutide · SUSTAIN-6. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would rather hear…
What I have: ATTAIN-1 · constipation. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…
What I have: 1.7 mg · dulaglutide. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the minimum viable…
Conditions: SUSTAIN-6 · dizziness · 2.4 mg. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single…
Conditions: nausea · retatrutide · TRIUMPH-3. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…
What I have: ESSENCE · 2 mg. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s interpretation…
What I have: SOUL · oral semaglutide. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…
Setup, so nobody has to ask: STEP 3 · a GLP-1 receptor agonist. I have read the primary source rather than the summary, which has left me with more questions. I…
The particulars: oral semaglutide · 30 °C. Somebody stated this to me confidently and I would like to check it before repeating it. I would accept a well-reasoned…
What I am working with: ESSENCE · semaglutide. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single…
Conditions: SURMOUNT-5 · tirzepatide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and monographs…
What I have: a GLP-1 receptor agonist · cagrilintide. I have used one of these for a while and I am considering switching, which requires a reason. What I care about…
I have three data points across nine months, which I hope is enough to see a trend. I would like the arithmetic checked rather than the conclusion asserted. I have…
Stated plainly: cagrilintide · liraglutide. I have used one of these for a while and I am considering switching, which requires a reason. What I care about is…
The specifics, since they change the answer: STEP 5 · early satiety. I have the document in front of me and I can read the numbers. What I cannot do is interpret…
Concretely: SURMOUNT-OSA · tirzepatide. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…
Details up front: a GLP-1 receptor agonist · ESSENCE. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…
Numbers first: 36 mg · orforglipron. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the minimum viable…
Setup, so nobody has to ask: TRIUMPH-1 · dizziness · 8 mg. I would like help reading this properly rather than being told what conclusion to reach. I have the full…
For reference: PIONEER-4 · 14 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably comfortable with…